Physical properties of solid dispersions of poorly water-soluble drugs with enteric coating agents.

Supersaturation mechanism of drugs from solid dispersions with enteric coating agents.

phenomena from solid dispersions with enteric coating agents in JP XI 2nd fluid(pH 6.8). Nifedipine,griseofulvin and spironolactone were used as drugs.The rate of crystallization of all drugs was remarkably inhibited by the presence of CMEC.It was found that the inhibition was not due to solubilization of the drugs by CMEC. The crystallization kinetics from supersaturated solutions suggested th...

Solid Dispersions: An Overview To Modify Bioavailability Of Poorly Water Soluble Drugs

Solubility Enhancement of Poorly Water Soluble Drugs by Solid Dispersion

Solid dispersions have been employed to enhance the dissolution rates of poorly water-soluble drugs. Many approaches have been investigated for the preparation of solid dispersions. This paper reports the various solubility enhancement strategies in solid dispersion. The approaches described are fusion (melting), solvent evaporation, lyophilization (freeze drying), melt agglomeration process, e...

Hydrotropic solubilization of poorly water-soluble drugs.

The solubilizing ability of two aromatic hydrotropes, N,N-diethylnicotinamide (DENA) and N,N-dimethylbenzamide (DMBA), was investigated using a set of 13 poorly soluble, structurally diverse drugs. The number of aromatic rings in the solute molecule has a very strong effect on the solubility enhancement produced by either hydrotrope. However, although solubility enhancements in the order of 100...

Solubility Enhancement of a Poorly Water Soluble Drug by Forming Solid Dispersions using Mechanochemical Activation

Mechanochemical activation is a practical cogrinding operation used to obtain a solid dispersion of a poorly water soluble drug through changes in the solid state molecular aggregation of drug-carrier mixtures and the formation of noncovalent interactions (hydrogen bonds) between two crystalline solids such as a soluble carrier, lactose, and a poorly soluble drug, indomethacin, in order to impr...